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Biofabrication for the eardrum
Current approaches used for eardrum repair or replacement show sub-optimal hearing outcomes. 4NanoEARDRM aims at filling an exposed gap in COM treatment by providing biomimetic, reliable and highly performant eardrum devices provided with targeted drug delivery and anti-inflammatory activity, finally enabling in situ tympanic membrane regeneration with optimal acoustics. The 4NanoEARDRM device is conceived to be “4 times” “nano”, as it will have nanofibres supportive for cell repopulation, immunomodulatory nanofibrils, drug-delivery nanoparticles, and nanoscale vibration. At the same time, it will be “for” “Nano”, namely, for enabling exploitable nanotechnologies and nanomedicine products in otologic surgery.
As part of a Euronanomed project, we will be working together with partners from Italy, Germany, and Turkey.